Corpus ID: 40784542

New Inhibitors of the DENV-NS 5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment

  title={New Inhibitors of the DENV-NS 5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment},
  author={Paul Coulerie and Alexandre Maciuk and C{\'e}cilia Eydoux and Edouard Hnawia and Nicolas Lebouvier and Bruno Figad{\`e}re and Jean Claude Guillemot and Mohammed Nour},
Since a few decades the dengue virus became a major public health concern and no treatment is available yet. In order to propose potential antide ngue compounds for chemotherapy we focused on DENV R A polymerase (DENV-NS5 RdRp) which is specific and es sential for the virus replication. Carpolepis laurifolia belongs to the Myrtaceae and is used as febrifuge i n traditional kanak medicine. Leaf extract of this plant has been identified as a hit against the DENV-NS5 RdRp. Here we present a… Expand

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