New INH-pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity.

Abstract

With the aim of developing promising antitubercular and antibacterial leads, we have designed and synthesized a new series of isonicotinohydrazide based pyrazole derivatives (5a-r). All new derivatives (4a-b and 5a-r) were screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) strain. Four compounds 5j, 5k, 5l and 4b… (More)
DOI: 10.1016/j.bmcl.2015.10.057

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