New Hippocampal Neurons Mature Rapidly in Response to Ketamine But Are Not Required for Its Acute Antidepressant Effects on Neophagia in Rats123

@inproceedings{Soumier2016NewHN,
  title={New Hippocampal Neurons Mature Rapidly in Response to Ketamine But Are Not Required for Its Acute Antidepressant Effects on Neophagia in Rats123},
  author={Am{\'e}lie Soumier and Rayna M. Carter and Timothy J. Schoenfeld and Heather A. Cameron},
  booktitle={eNeuro},
  year={2016}
}
Virtually all antidepressant agents increase the birth of granule neurons in the adult dentate gyrus in rodents, providing a key basis for the neurogenesis hypothesis of antidepressant action. The novel antidepressant ketamine, however, shows antidepressant activity in humans within hours, far too rapid for a mechanism involving neuronal birth. Ketamine… CONTINUE READING