New Giemsa method for the differential staining of sister chromatids

@article{Perry1974NewGM,
  title={New Giemsa method for the differential staining of sister chromatids},
  author={Paul Perry and Sheldon Wolff},
  journal={Nature},
  year={1974},
  volume={251},
  pages={156-158}
}
IF human lymphocytes1 or Chinese hamster2 cells are treated with the base analogue 5-bromodeoxyuridine (BrdU) in the latter part of the S period, Giemsa stained chromosomes exhibit a pattern of condensed and extended segments along their length. This phenomenon has been attributed to a delay in the spiralisation pattern of the late replicating regions along the chromosomes. Other experiments3 with Chinese hamster ovary (CHO) cells have shown that after two rounds of replication in the presence… CONTINUE READING
Highly Influential
This paper has highly influenced 31 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 720 extracted citations

Similar Papers

Loading similar papers…