New Giemsa method for the differential staining of sister chromatids

  title={New Giemsa method for the differential staining of sister chromatids},
  author={Paul Perry and Sheldon Wolff},
IF human lymphocytes1 or Chinese hamster2 cells are treated with the base analogue 5-bromodeoxyuridine (BrdU) in the latter part of the S period, Giemsa stained chromosomes exhibit a pattern of condensed and extended segments along their length. This phenomenon has been attributed to a delay in the spiralisation pattern of the late replicating regions along the chromosomes. Other experiments3 with Chinese hamster ovary (CHO) cells have shown that after two rounds of replication in the presence… CONTINUE READING
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