New Family of Tungstate-Responsive Transcriptional Regulators in Sulfate-Reducing Bacteria

@article{Kazakov2013NewFO,
  title={New Family of Tungstate-Responsive Transcriptional Regulators in Sulfate-Reducing Bacteria},
  author={Alexey E Kazakov and Lara Rajeev and Eric G. Luning and Grant M. Zane and Kavya Siddartha and Dmitry A. Rodionov and Inna Dubchak and Adam Paul Arkin and Judy D. Wall and Aindrila Mukhopadhyay and Pavel S. Novichkov},
  journal={Journal of Bacteriology},
  year={2013},
  volume={195},
  pages={4466 - 4475}
}
ABSTRACT The trace elements molybdenum and tungsten are essential components of cofactors of many metalloenzymes. However, in sulfate-reducing bacteria, high concentrations of molybdate and tungstate oxyanions inhibit growth, thus requiring the tight regulation of their homeostasis. By a combination of bioinformatic and experimental techniques, we identified a novel regulator family, tungstate-responsive regulator (TunR), controlling the homeostasis of tungstate and molybdate in sulfate… 
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