New Family of Deamination Repair Enzymes in Uracil-DNA Glycosylase Superfamily*

  title={New Family of Deamination Repair Enzymes in Uracil-DNA Glycosylase Superfamily*},
  author={Hyun-wook Lee and Brian N. Dominy and Weiguo Cao},
  journal={The Journal of Biological Chemistry},
  pages={31282 - 31287}
DNA glycosylases play a major role in the repair of deaminated DNA damage. Previous investigations identified five families within the uracil-DNA glycosylase (UDG) superfamily. All enzymes within the superfamily studied thus far exhibit uracil-DNA glycosylase activity. Here we identify a new class of DNA glycosylases in the UDG superfamily that lacks UDG activity. Instead, these enzymes act as hypoxanthine-DNA glycosylases in vitro and in vivo. Molecular modeling and structure-guided mutational… 

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