New Environment-Sensitive Multichannel DNA Fluorescent Label for Investigation of the Protein-DNA Interactions

@inproceedings{Kuznetsova2014NewEM,
  title={New Environment-Sensitive Multichannel DNA Fluorescent Label for Investigation of the Protein-DNA Interactions},
  author={Alexandra A. Kuznetsova and Nikita A Kuznetsov and Yuri N. Vorobjev and Nicolas P F Barthes and Beno{\^i}t Y Michel and Alain Burger and Olga S Fedorova},
  booktitle={PloS one},
  year={2014}
}
Here, we report the study of a new multichannel DNA fluorescent base analogue 3-hydroxychromone (3HC) to evaluate its suitability as a fluorescent reporter probe of structural transitions during protein-DNA interactions and its comparison with the current commercially available 2-aminopurine (aPu), pyrrolocytosine (Cpy) and 1,3-diaza-2-oxophenoxazine (tCO). For this purpose, fluorescent base analogues were incorporated into DNA helix on the opposite or on the 5'-side of the damaged nucleoside 5… CONTINUE READING
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