New ELISA-based method for the detection of O-GlcNAc transferase activity in vitro.

Abstract

O-GlcNAcylation is a dynamic, reversible, post-translational modification that regulates many cellular processes. O-GlcNAc transferase (OGT) is the sole enzyme transferring N-acetylglucosamine from uridine diphosphate (UDP)-GlcNAc to selected serine/threonine residues of cytoplasm and nucleus proteins. Aberrant of OGT activity is associated with several… (More)
DOI: 10.1080/10826068.2017.1303614

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