New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets

@inproceedings{Friesen2010NewCO,
  title={New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets},
  author={Robert H. E. Friesen and Wouter Koudstaal and Martin H. Koldijk and Gerrit Jan Weverling and Just P. J. Brakenhoff and Peter J Lenting and Koert J. Stittelaar and Albert D. M. E. Osterhaus and Ronald Kompier and Jaap Goudsmit},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The urgent medical need for innovative approaches to control influenza is emphasized by the widespread resistance of circulating subtype H1N1 viruses to the leading antiviral drug oseltamivir, the pandemic threat posed by the occurrences of human infections with highly pathogenic avian H5N1 viruses, and indeed the evolving swine-origin H1N1 influenza pandemic. A recently discovered class of human monoclonal antibodies with the ability to neutralize a broad spectrum of influenza… CONTINUE READING

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