New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups.

@article{Xie2016NewCR,
  title={New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups.},
  author={Chen Xie and Lijun Zhang and Haibo Mei and Romana Pajkert and Maksym V Ponomarenko and Yi Pan and G V R{\"o}schenthaler and Vadim A Soloshonok and Jianlin Han},
  journal={Chemistry},
  year={2016},
  volume={22 21},
  pages={7036-40}
}
A new chiral reagent has been developed for generalized installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2-difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel-Crafts reactions with indoles, which proceed efficiently with excellent diastereoselectivity to give enantiomerically pure products.