New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

  title={New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs},
  author={Dominik Sturm and Brent A. Orr and Umut H. Toprak and Volker Hovestadt and David T. W. Jones and David R. Capper and Martin Sill and Ivo Buchhalter and Paul A. Northcott and Irina Leis and Marina Ryzhova and Christian Koelsche and Elke Pfaff and Sariah J. Allen and Gnanaprakash Balasubramanian and Barbara C. Worst and Kristian W Pajtler and Sebastian Brabetz and Pascal Johann and Felix Sahm and J{\"u}ri Reimand and Alan Mackay and Diana Maul de Carvalho and Marc Remke and Joanna J Phillips and Arie Perry and Cynthia J Cowdrey and Rachid Drissi and Maryam Fouladi and Felice Giangaspero and Maria Łastowska and Wiesława Grajkowska and Wolfram Scheurlen and Torsten Pietsch and Christian Hagel and Johannes Gojo and Daniela L{\"o}tsch and Walter Berger and Irene Slavc and Christine Haberler and Anne Jouvet and Stefan Rub{\ae}k Holm and Silvia Hofer and Marco Prinz and Catherine Keohane and Iris Fried and Christian Mawrin and David Scheie and Bret C. Mobley and Matthew J. Schniederjan and Mariarita R Santi and Anna Maria Buccoliero and Sonika Dahiya and Christof Maria Kramm and Andr{\'e} O. von Bueren and Katja von Hoff and Stefan Rutkowski and Christel Herold-Mende and Michael Christoph Fr{\"u}hwald and Till Milde and Martin Hasselblatt and Pieter Wesseling and Jochen R{\"o}ssler and Ulrich Sch{\"u}ller and Martin Ebinger and Jens Schittenhelm and Stephan Frank and Rainer Grobholz and Istvan Vajtai and V. Basil Hans and Reinhard Schneppenheim and Karel Zitterbart and Vincent Peter Collins and E. Aronica and Pascale Varlet and S Puget and Christelle Dufour and J Grill and Dominique F. Figarella-Branger and Marietta Wolter and Martin Schuhmann and Tarek Al Shalaby and Michael Andreas Grotzer and Timothy E. Van Meter and Camelia Maria Monoranu and Joerg Felsberg and Guido Reifenberger and M Snuderl and Lynn Ann Forrester and Jan T. A. Koster and Rogier Versteeg and Richard Volckmann and Peter van Sluis and Stephan Wolf and Tom Mikkelsen and Amar Gajjar and Kenneth D. Aldape and Andrew S Moore and Michael D. Taylor and Chris Jones and Nada Jabado and Matthias A Karajannis and Roland Eils and Matthias Schlesner and Peter Lichter and Andreas von Deimling and Stefan M. Pfister and D W Ellison and Andrey Korshunov and Marcel Kool},
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors… CONTINUE READING
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