New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China

@article{Ji2008NewBS,
  title={New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China},
  author={Kun-mei Ji and Chunlin Li and Guang Meng and Ai-Dong Han and Xuli Wu},
  journal={Archives of Virology},
  year={2008},
  volume={153},
  pages={1949-1953}
}
The viral lytic gene BZLF1 triggers replication of the Epstein–Barr virus (EBV), which is commonly found in nasopharyngeal carcinoma (NPC). Here, RT-PCR revealed five new BZLF1 variants in 8 of 12 NPC and 4 of 12 non-NPC nasopharyngeal biopsies from an NPC-endemic area in southern China. The deduced peptide sequence of the dominant BZLF1 variant differed by 11 amino acids from that of the prototypical strain B95.8 (V01555). Anti-ZEBRA antibody levels were higher in NPC than that in non-NPC… CONTINUE READING

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