New B-lymphocyte-specific enhancer-binding protein.

  title={New B-lymphocyte-specific enhancer-binding protein.},
  author={August Dorn and C. Benoist and Diane Mathis},
  journal={Molecular and cellular biology},
  volume={9 1},
We report the discovery of a new B-lymphocyte-specific enhancer-binding protein. A series of gel retardation assays using fragments that scan the -2172 to -1180 region of the major histocompatibility complex class II gene E alpha reveal a site (W) that serves as the recognition sequence for two nuclear proteins, one B-cell restricted and the other ubiquitously occurring. Certain characteristics of the NF-W1 and NF-W2 pair recall the OTF-2/NF-A2 and OTF-1/NF-A1 pair that binds to the… CONTINUE READING