New Antibody Conjugates in Cancer Therapy

  title={New Antibody Conjugates in Cancer Therapy},
  author={Serengulam V. Govindan and David M. Goldenberg},
Targeting of radiation, drugs, and protein toxins to cancers selectively with monoclonal antibodies (MAbs) has been a topic of considerable interest and an area of continued development. Radioimmunotherapy (RAIT) of lymphoma using directly labeled MAbs is of current interest after approval of two radiolabeled anti-CD20 MAbs, as illustrated with the near 100% overall response rate obtained in a recent clinical trial using an investigational radiolabeled anti-CD22 MAb, 90Y-epratuzumab. The… CONTINUE READING
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  • Proc. Am. Assoc. Cancer Res
  • 2010
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  • 2010
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