New Antibody Conjugates in Cancer Therapy

@inproceedings{Govindan2010NewAC,
  title={New Antibody Conjugates in Cancer Therapy},
  author={Serengulam V. Govindan and David M. Goldenberg},
  booktitle={TheScientificWorldJournal},
  year={2010}
}
Targeting of radiation, drugs, and protein toxins to cancers selectively with monoclonal antibodies (MAbs) has been a topic of considerable interest and an area of continued development. Radioimmunotherapy (RAIT) of lymphoma using directly labeled MAbs is of current interest after approval of two radiolabeled anti-CD20 MAbs, as illustrated with the near 100% overall response rate obtained in a recent clinical trial using an investigational radiolabeled anti-CD22 MAb, 90Y-epratuzumab. The… CONTINUE READING
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A novel immunotoxin comprising quadruple RNase tethered to an internalizing anti-TROP-2 humanized MAb shows potent cytotoxicity against diverse solid tumors in vitro

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