New Antiarrhythmic drugs in pediatric use: Amiodarone

@article{Paul1994NewAD,
  title={New Antiarrhythmic drugs in pediatric use: Amiodarone},
  author={Thomas Paul and Paolo Guccione},
  journal={Pediatric Cardiology},
  year={1994},
  volume={15},
  pages={132-138}
}
Amiodarone, a class III antiarrhythmic agent, prolongs action potential duration and refractoriness of all cardiac structures. The drug is more rapidly metabolized in pediatric patients than in adults, but its kinetics are still unique compared with other drugs. Due to the unusual pharmacokinetic characteristics of amiodarone, treatment has to be started by administering loading doses, and there is a significant delay both in the achievement of the full antiarrhythmic effect and in the… CONTINUE READING

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