New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity

  title={New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity},
  author={Gilles Eric S{\'e}ralini and Dominique Cellier and Jo{\"e}l Spiroux de Vend{\^o}mois},
  journal={Archives of Environmental Contamination and Toxicology},
Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological… 

Genetically modified crops safety assessments: present limits and possible improvements

The 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers could be the onset of chronic diseases.

Biological impact of feeding rats with a genetically modified-based diet

The results indicate that there are health hazards linked to the ingestion of diets containing genetically modified components, and that the GM diet fed to rats for 30, 60, or 90 days has deleterious histopathological and histochemical impacts.

A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health

Comparison of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize reveals new side effects linked with GM maize consumption, which were sex- and often dose-dependent.

Rat feeding studies with genetically modified maize - a comparative evaluation of applied methods and risk assessment standards

A 2-year rat feeding study with genetically modified NK603 maize sparked an international scientific and public debate as well as policy responses by the European Commission. The European Food Safety

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

An improved safety assessment animal model is constructed using a basic subchronic toxicity experiment, measuring a range of parameters including microflora composition, intestinal permeability, epithelial structure, fecal enzymes, bacterial activity, and intestinal immunity and may offer a systematic safety assessment model for GM material with respect to the effects on GI health.

Nutritional Assessment of Dietary Bt and Cp4EPSPS Proteins on the Serum Biochemical Changes of Rabbits at Different Developmental Stages

Results suggested that the GM cotton seed meal could be considered as safe as other conventional feed ingredients, and the experimental evidence for the safe usage of GM cotton was highlighted in this study.

GM crops and the rat digestive tract: a critical review.

Genetically modified crop consumption at large scale : Possible negative health impacts due to holes in assessment . Overview of the safety studies of GMOs performed on mammals 1

The raw data of several safety, 28 day or 90 day long, in vivo tests on rats for GMOs are obtained and the results are reviewed in the light of modern scientific knowledge.

The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial

Using this experimental design, no biomarkers of adverse health effect could be attributed to the consumption of GMP diets in comparison with the consumption with their near-isogenic non-GMP controls.

A literature review on the safety assessment of genetically modified plants.




Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn.

  • B. HammondJ. Lemen J. Burns
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006
This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties.

Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn.

  • B. HammondR. DudekJ. LemenM. Nemeth
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006

Ultrastructural analysis of testes from mice fed on genetically modified soybean.

The results point out that the immunolabelling for Sm antigen, hnRNPs, SC35 and RNA Polymerase II is decreased in 2 and 5 month-old GM-fed mice, and is restored to normal at 8 months, and the number of perichromatin granules is higher and the nuclear pore density lower.

Ovarian function during aflatoxin B1-induced hepatocarcinogenesis in the rat.

The endocrine reaction implicated in the development of tumors during carcinogenesis thus appears closely related to the nature of the carcinogen, AFP production, and the composition of the diet.

Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase

It is shown that glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use, and this effect increases with concentration and time, and the presence of Roundup adjuvants enhances glyphosate bioavailability and/or bioaccumulation.

Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean.

The data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown.

Effects of Bacillus thuringiensis toxin on hepatic lipid peroxidation and free-radical scavengers in rats given alpha-tocopherol or acetylsalicylate.

Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment

Because CPN is a rodent-specific entity, the finding of a small, statistically significant increase in renal tubule tumors, linked to exacerbation of CPN by a test chemical in a preclinical study for carcinogenicity, can be regarded as having no relevance for extrapolation in human risk assessment.

Ethical acceptability, health policy and foods biotechnology based foods: is there a third way between the precaution principle and an overly enthusiastic dissemination of GMO?

This work suggests that the scientific community and the food-processing industry develop evaluation protocols for new foods like the ones that exist for drugs, and offers thirteen regulations, based on the Helsinki declaration, in order to establish these protocols.

Role of hydrazine in the mechanism of isoniazid hepatotoxicity in rabbits

It is shown in this model of INH-induced hepatotoxicity in rabbits that hydrazine, and not INH or acetylhydrazines, is most likely involved in the pathogenic mechanism of hepatic necrosis.