New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity

@article{Sralini2007NewAO,
  title={New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity},
  author={Gilles Eric S{\'e}ralini and Dominique Cellier and Jo{\"e}l Spiroux de Vend{\^o}mois},
  journal={Archives of Environmental Contamination and Toxicology},
  year={2007},
  volume={52},
  pages={596-602}
}
Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological… 

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References

SHOWING 1-10 OF 30 REFERENCES

Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn.

  • B. HammondJ. Lemen J. Burns
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006
This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties.

Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn.

  • B. HammondR. DudekJ. LemenM. Nemeth
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006

Ultrastructural analysis of testes from mice fed on genetically modified soybean.

The results point out that the immunolabelling for Sm antigen, hnRNPs, SC35 and RNA Polymerase II is decreased in 2 and 5 month-old GM-fed mice, and is restored to normal at 8 months, and the number of perichromatin granules is higher and the nuclear pore density lower.

Ovarian function during aflatoxin B1-induced hepatocarcinogenesis in the rat.

The endocrine reaction implicated in the development of tumors during carcinogenesis thus appears closely related to the nature of the carcinogen, AFP production, and the composition of the diet.

Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase

It is shown that glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use, and this effect increases with concentration and time, and the presence of Roundup adjuvants enhances glyphosate bioavailability and/or bioaccumulation.

Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean.

The data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown.

Effects of Bacillus thuringiensis toxin on hepatic lipid peroxidation and free-radical scavengers in rats given alpha-tocopherol or acetylsalicylate.

Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment

Because CPN is a rodent-specific entity, the finding of a small, statistically significant increase in renal tubule tumors, linked to exacerbation of CPN by a test chemical in a preclinical study for carcinogenicity, can be regarded as having no relevance for extrapolation in human risk assessment.

Ethical acceptability, health policy and foods biotechnology based foods: is there a third way between the precaution principle and an overly enthusiastic dissemination of GMO?

This work suggests that the scientific community and the food-processing industry develop evaluation protocols for new foods like the ones that exist for drugs, and offers thirteen regulations, based on the Helsinki declaration, in order to establish these protocols.

Role of hydrazine in the mechanism of isoniazid hepatotoxicity in rabbits

It is shown in this model of INH-induced hepatotoxicity in rabbits that hydrazine, and not INH or acetylhydrazines, is most likely involved in the pathogenic mechanism of hepatic necrosis.