New 2-thiopyridines as potential candidates for killing both actively growing and dormant Mycobacterium tuberculosis cells.

@article{Salina2014New2A,
  title={New 2-thiopyridines as potential candidates for killing both actively growing and dormant Mycobacterium tuberculosis cells.},
  author={Elena G. Salina and Olga B. Ryabova and Arseny S. Kaprelyants and Vadim A. Makarov},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 1},
  pages={55-60}
}
From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attempts, no specific antimicrobials effective against latent tuberculosis have yet been found, partly because of a lack of reliable and adequate in vitro models for screening of drug candidates. We propose here a novel in vitro model of M. tuberculosis… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 31 references

Mycobacterium: isolation, maintenance, transformation, and mutant selection.

Methods in cell biology • 1994
View 3 Excerpts
Highly Influenced

The probability of most probable numbers

JC deMan
J. Appl. Microbiol • 1975
View 4 Excerpts
Highly Influenced

Targeting persisters for tuberculosis

Y Zhang, WW Yew, MR. Barer
control. Antimicrob. Agents Chemother. 56:2223–2230 • 2012

Targeting persisters for tuberculosis control.

Antimicrobial agents and chemotherapy • 2012
View 1 Excerpt

Recent developments in treatment of latent tuberculosis infection

D Menzies, H Al Jahdali, B. Al Otaibi
Indian J. Med. Res • 2011
View 1 Excerpt

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