New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents.

@article{Zagotto2000New1D,
  title={New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents.},
  author={Giuseppe Zagotto and Rosanna Supino and Enrica Favini and Stefano Moro and Manlio Palumbo},
  journal={Farmaco},
  year={2000},
  volume={55 1},
  pages={1-5}
}
The amino-substituted anthracene-9,10-dione (9,10-anthraquinone) derivatives represent one of the most important classes of potential anticancer agents. To better understand the basic rules governing DNA sequence specificity, we have recently synthesized a new class of D- and L-aminoacyl-anthraquinone derivatives. We have tested these new compounds as cytotoxic agents, and we have correlated their activity with the configuration of the chiral aminoacyl moiety. Molecular modeling studies have… CONTINUE READING