New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.

@article{Schenone2006New1D,
  title={New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.},
  author={Silvia Schenone and Chiara Brullo and O. A. Bruno and Francesco Bondavalli and Angelo Ranise and Walter Filippelli and Barbara Rinaldi and Annalisa Capuano and Giuseppe Falcone},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 6},
  pages={1698-705}
}
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low. 

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