New β-lactam antibiotics and β-lactamase inhibitors.

  title={New β-lactam antibiotics and β-lactamase inhibitors.},
  author={Karen Bush and Mark J Macielag},
  journal={Expert opinion on therapeutic patents},
  volume={20 10},
IMPORTANCE OF THE FIELD β-Lactam antibiotics are among the most frequently prescribed antibiotics used to treat bacterial infections. However, their utility is being threatened by the worldwide proliferation of β-lactamases with broad hydrolytic capabilities, especially in multidrug-resistant Gram-negative bacteria. AREAS COVERED IN THIS REVIEW This review describes new β-lactams and β-lactamase inhibitors described in the patent literature primarily between 2007 and 2010, together with… CONTINUE READING
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