New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.

@article{Liao1999NewA,
  title={New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.},
  author={Yusheng Liao and Bastiaan Johan Venhuis and Nienke Rodenhuis and Wia Timmerman and H{\aa}kan Wikstr{\"o}m and E. de Meier and Gerd D. Bartoszyk and Henning Boettcher and Christoph A. Seyfried and Staffan Sundell},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 12},
  pages={2235-44}
}
A series of 2- or 8-trifluoromethylsulfonyloxy (TfO) and 2- or 8-methylsulfonyloxy (MsO) 11-piperazinyldibenzodiazepines, -oxazepines, and -thiazepines were synthesized and evaluated in pharmacological models for their potential clozapine-like properties. In receptor binding assays, the 2-TfO analogues (18a, GMC2-83; 24, GMC3-06; and previously reported GMC1-169, 9a) of the dibenzazepines have profiles comparable to that of clozapine, acting on a variety of CNS receptors except they lack M1… CONTINUE READING