Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo.

@article{Landriscina2009NevirapineRA,
  title={Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo.},
  author={Matteo Landriscina and Cinzia Bagal{\`a} and Annamaria Piscazzi and Giovanni Schinzari and Michela Quirino and Annarita Fabiano and Sara Bianchetti and Alessandra Cassano and Gigliola Sica and Carlo Barone},
  journal={The Prostate},
  year={2009},
  volume={69 7},
  pages={744-54}
}
BACKGROUND Prostate carcinomas are androgen-dependent neoplasms which progress toward a hormone-independent phenotype during hormone-deprivation therapy. We evaluated nevirapine, a reverse transcriptase inhibitor, as a new treatment in hormone-refractory prostate carcinoma cells with the aim of restoring the androgen-dependency of tumor cells, the rationale being that endogenous reverse transcriptase is up-regulated in transformed cells and reverse transcriptase inhibitors exert a… CONTINUE READING

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