Nevirapine plasma concentrations and concomitant use of rifampin in patients coinfected with HIV-1 and tuberculosis.

@article{Autar2005NevirapinePC,
  title={Nevirapine plasma concentrations and concomitant use of rifampin in patients coinfected with HIV-1 and tuberculosis.},
  author={Reshma Saskia Autar and Ferdinand W. N. M. Wit and Jongkol Sankote and Apicha Mahanontharit and Thanomsak Anekthananon and Piroon Mootsikapun and Khanjtta Sujaikaew and David A. Cooper and Joep M. A. Lange and Praphan Phanuphak and Kiat Ruxrungtham and David M Burger},
  journal={Antiviral therapy},
  year={2005},
  volume={10 8},
  pages={937-43}
}
OBJECTIVES In countries with high numbers of HIV/tuberculosis coinfection nevirapine and rifampin are used extensively. However, limited data are available about whether or not nevirapine and rifampin can be safely coadministered without the plasma concentration of nevirapine falling below therapeutic levels. METHODS Blood samples for determination of nevirapine plasma concentrations were collected from patients using nevirapine 200 mg twice daily with or without concomitant rifampin… CONTINUE READING