Nevirapine derivatives with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.

Abstract

A series of nevirapine derivatives has been synthesized in an effort to enhance the spectrum of chemotherapeutic properties for the effective treatment of AIDS and AIDS-related opportunistic infections. The nevirapine derivative bearing isoniazid moiety (3a) was found to be the most potent compound with EC50 of<0.0636 microM, CC50 of>1000 microM and selectivity index of>15,723 which also exhibited 90% inhibition against Mycobacterium tuberculosis at 6.25 microg/ml. Compound 3c showed 100% inhibition against M. tuberculosis and also exhibited potent antibacterial activity against 24 pathogenic bacteria with MIC less than 1 microg/ml.

Cite this paper

@article{Sriram2005NevirapineDW, title={Nevirapine derivatives with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.}, author={Dharmarajan Sriram and Narasimharaghavan Srichakravarthy and Tanushree Ratan Bal and Perumal Yogeeswari}, journal={Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie}, year={2005}, volume={59 8}, pages={456-9} }