Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis.

@article{Nishio1998NeutrophinSI,
  title={Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis.},
  author={Takeshi Nishio and Nobuhiko Sunohara and Shoei Furukawa},
  journal={Neuroreport},
  year={1998},
  volume={9 7},
  pages={1661-5}
}
To clarify the roles of neurotrophins in the human spinal motoneurons, with special reference to amyotrophic lateral sclerosis (ALS), we studied the immunohistochemical localizations of neurotrophins and their receptors in spinal cords of patients with ALS and compared them with controls. In the controls, the majority of motoneurons showed BDNF-, NT3-, trkB- and trkC-like immunoreactivity (-LI) suggesting that the motoneurons receive an autocrine regulation by both BDNF and NT3. In ALS patients… CONTINUE READING