Neutrophils scan for activated platelets to initiate inflammation

  title={Neutrophils scan for activated platelets to initiate inflammation},
  author={Vinatha Sreeramkumar and Jos{\'e} Mar{\'i}a Adrover and Iv{\'a}n Ballesteros and Mar{\'i}a Isabel Cuartero and Jan Rossaint and Izaskun Bilbao and Maria N{\'a}cher and Christophe Pitaval and Irena Radovanovic and Yoshinori Fukui and Rodger P McEver and M D Filippi and Ignacio Lizasoain and Jes{\'u}s Ru{\'i}z-Cabello and Alexander Zarbock and Mar{\'i}a {\'A}ngeles Moro and Andr{\'e}s Hidalgo},
Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the… CONTINUE READING