Neutrophils instruct homeostatic and pathological states in naive tissues.

@article{CasanovaAcebes2018NeutrophilsIH,
  title={Neutrophils instruct homeostatic and pathological states in naive tissues.},
  author={Mar{\'i}a Casanova-Acebes and Jos{\'e} A. Nicol{\'a}s-{\'A}vila and Jackson LiangYao Li and Susana Garc{\'i}a-Silva and Akhila Balachander and Andrea Rubio-Ponce and Linnea A. Weiss and Jos{\'e} Mar{\'i}a Adrover and Kyle Burrows and Noelia A-Gonz{\'a}lez and Iv{\'a}n Ballesteros and Sapna Devi and Juan Antonio Quintana and Georgiana Crainiciuc and Magdalena Leiva and Matthias Gunzer and Christian Weber and Takashi Nagasawa and Oliver Soehnlein and Miriam Merad and Arthur Mortha and Lai Guan Ng and H{\'e}ctor Peinado and Andr{\'e}s Hidalgo},
  journal={The Journal of experimental medicine},
  year={2018},
  volume={215 11},
  pages={
          2778-2795
        }
}
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by… CONTINUE READING
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