Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity

Abstract

INTRODUCTION Sepsis is characterized by systemic immune activation and neutrophil-mediated endothelial barrier integrity compromise, contributing to end-organ dysfunction. Studies evaluating endothelial barrier dysfunction induced by neutrophils from septic patients are lacking, despite its clinical significance. We hypothesized that septic neutrophils… (More)
DOI: 10.1186/cc13049

Topics

7 Figures and Tables