Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia.

@article{Gautier2009NeutrophilsCT,
  title={Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia.},
  author={Sophie Gautier and Thavarak Ouk and Olivier P{\'e}trault and J. Raymond Caron and R{\'e}gis Bordet},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 4},
  pages={673-9}
}
BACKGROUND AND PURPOSE Polymorphonuclear neutrophils (PMNs) contribute to the vascular damage caused by transient cerebral ischaemia. Here we have evaluated the role of PMNs in intracerebral haemorrhage (ICH) induced in a model of thrombolysis with recombinant tissue plasminogen activator (t-PA) during the acute phase of cerebral ischaemia. EXPERIMENTAL APPROACH The middle cerebral artery (MCA) of male spontaneously hypertensive rats was occluded for 1 h followed by reperfusion and, 5 h later… CONTINUE READING

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