Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release.

@article{Silva2004NeutrophilsAA,
  title={Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release.},
  author={Sueli de Oliveira Silva and Maria Rita Rodrigues and Valdecir Farias Ximenes and A E B Bueno-da-Silva and Gustavo Pessini Amarante-Mendes and Ana M. Sanchez de la Campa},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={156 1-2},
  pages={146-52}
}
A growing body of evidence suggests that the pineal hormone, melatonin, has immunomodulatory properties, although very little is known about its effect on leukocytes. Therefore, we aimed to investigate the effect of melatonin and its oxidation product N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) on cytokine production by neutrophils and peripheral blood mononuclear cells (PBMCs). AFMK (0.001-1 mM) inhibits the lipopolysaccharide (LPS)-mediated production of tumor necrosis factor-alpha (TNF… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
A growing body of evidence suggests that the pineal hormone , melatonin , has immunomodulatory properties , although very little is known about its effect on leukocytes .
A growing body of evidence suggests that the pineal hormone , melatonin , has immunomodulatory properties , although very little is known about its effect on leukocytes .
All Topics