Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation.

@article{Benelli2002NeutrophilsAA,
  title={Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation.},
  author={Roberto Benelli and Monica Morini and Fabio Carrozzino and Nicoletta Ferrari and Simona Minghelli and Leonardo Santi and Marco A Cassatella and Douglas M Noonan and Adriana Albini},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 2},
  pages={267-9}
}
Angiostatin effectively blocks tumor angiogenesis through still poorly understood mechanisms. Given the close association between immune and vascular regulation, we investigated the effects of angiostatin on angiogenesis-associated leukocytes. Angiostatin inhibited the migration of monocytes and, even more markedly, neutrophils. Angiostatin blocked chemotaxis of neutrophils to CXCR2 chemokine receptor agonists (IL-8, MIP-2, and GROalpha), formyl-Met-Leu-Phe (fMLP), and 12-O-tetradecanoylphorbol… CONTINUE READING

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Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation

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