Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice.

@article{Pruijt2002NeutrophilsAI,
  title={Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice.},
  author={Johannes F. M. Pruijt and Perry Verzaal and Ronald van Os and Evert-Jan F M de Kruijf and Marianke L J van Schie and Alberto Mantovani and Annunciata Vecchi and Ivan J. D. Lindley and Roel Willemze and Sofie Starckx and Ghislain Opdenakker and Willem E. Fibbe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 9},
  pages={6228-33}
}
The CXC chemokine interleukin-8 (IL-8/CXCL8) induces rapid mobilization of hematopoietic progenitor cells (HPCs). Previously we showed that mobilization could be prevented completely in mice by pretreatment with neutralizing antibodies against the beta2-integrin LFA-1 (CD11a). In addition, murine HPCs do not express LFA-1, indicating that mobilization requires a population of accessory cells. Here we show that polymorphonuclear cells (PMNs) serve as key regulators in IL-8-induced HPC… CONTINUE READING
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