Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody

@article{Conlan1994NeutrophilsAE,
  title={Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody},
  author={J. Wayne Conlan and Robert J. North},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={259 - 268}
}
This study shows that in mice selectively depleted of neutrophils by treatment with a monoclonal antibody, RB6-8C5, listeriosis is severely exacerbated in the liver, but not in the spleen or peritoneal cavity during the crucial first day of infection. At sites of infection in the livers of neutrophil-depleted mice, Listeria monocytogenes grew to large numbers inside hepatocytes. By contrast, in the livers of normal mice neutrophils rapidly accumulated at infectious foci and this was associated… CONTINUE READING

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Experimental Listeria enteritis. I. An electron microscopic study of the epithelial phase in experimental listeria infection.

Laboratory investigation; a journal of technical methods and pathology • 1972
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