Neutrophils and immunity: challenges and opportunities

@article{Nathan2006NeutrophilsAI,
  title={Neutrophils and immunity: challenges and opportunities},
  author={Carl F. Nathan},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={173-182}
}
  • C. Nathan
  • Published 1 March 2006
  • Biology, Medicine
  • Nature Reviews Immunology
Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune… Expand

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References

SHOWING 1-10 OF 116 REFERENCES
Tissue destruction by neutrophils.
  • S. Weiss
  • Medicine
  • The New England journal of medicine
  • 1989
WITH increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusionExpand
Points of control in inflammation
TLDR
The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response. Expand
Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN
TLDR
It is shown that activated, not resting, neutrophils induce maturation of DCs that enables these DCs to trigger strong T cell proliferation and T helper type 1 polarization of T cells, and that besides the formation of cellular contact, the tumor necrosis factor-α produced by activated neutrophil is essential for inducing DC maturation. Expand
Neutrophil-Mediated Maturation of Chemerin: A Link between Innate and Adaptive Immunity1
TLDR
It is demonstrated here that human degranulated PMNs release proteases that efficiently convert prochemerin into active chemerin, underscoring the functional contribution ofChemerin as a bridge between innate and adaptive immunity. Expand
Neutrophil function in the healing wound: adding insult to injury?
TLDR
Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure, and suggests that the functional role of inflammatory cells in wound healing must be reevaluated. Expand
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
TLDR
It is shown that mice made deficient in neutrophil-granule proteases but normal in respect of superoxide production and iodinating capacity, are unable to resist staphylococcal and candidal infections. Expand
Neutrophil granules and secretory vesicles in inflammation.
TLDR
This review summarises current knowledge of granule biology and highlights the effects of neutrophil degranulation in the acute inflammatory response. Expand
Myeloperoxidase: friend and foe
  • S. Klebanoff
  • Biology, Medicine
  • Journal of leukocyte biology
  • 2005
TLDR
It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes and the role of theMPO system in tissue injury. Expand
Granulocyte clearance by apoptosis in the resolution of inflammation.
TLDR
The balance between granulocytes apoptosis and necrosis in inflamed tissues may be an important determinant of the degree of tissue injury, and further dissection of the mechanisms of granulocyte apoptotic removal may lead to new therapeutic strategies in inflammatory disease. Expand
The acquired immune system: a vantage from beneath.
TLDR
The susceptibility pattern of the two mouse strains is exactly the reverse for infection with the parasitic protozoan Toxoplasma gondii, and a combination of genomics and immunopathology will surely uncover the subtle changes in the immune system that can dramatically affect virulence and the outcome of an infection. Expand
...
1
2
3
4
5
...