Neutrophils and acute lung injury

@article{Abraham2003NeutrophilsAA,
  title={Neutrophils and acute lung injury},
  author={Edward Abraham},
  journal={Critical Care Medicine},
  year={2003},
  volume={31},
  pages={S195-S199}
}
  • E. Abraham
  • Published 1 April 2003
  • Medicine, Biology
  • Critical Care Medicine
ObjectiveNeutrophils are an important component of the inflammatory response that characterizes acute lung injury (ALI). This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil activation in the setting of ALI. Data SourcesMEDLINE, original research papers, and review papers. Study SelectionRelevant laboratory and clinical studies. Data ExtractionSystemic… 
Acute Lung Injury:Apoptosis and Signaling Mechanisms
TLDR
The results support the concept that the upregulation of apoptosis following lung inflammation plays a crucial role in the development of acute lung injury and related disorders such as ARDS.
Contribution of Neutrophils to Acute Lung Injury
TLDR
This review focuses on the mechanisms of neutrophil recruitment into the lung and on the contribution of Neutrophils to tissue damage in ALI.
Friend or foe? The dual role of neutrophils in lung injury and repair
TLDR
The evidence suggests that neutrophils are centrally implicated in the onset and progression of ALI, where endothelial and epithelial injuries are associated with microvascular permeability, increased tissue oedema and an early accumulation of activated neutrophil to the lung.
Epithelial Cell Apoptosis and Neutrophil Recruitment in Acute Lung Injury—A Unifying Hypothesis? What We Have Learned from Small Interfering RNAs
TLDR
The contribution that Fas-mediated inflammation may play as a potential biological link between lung cell apoptosis and PMN recruitment will be considered, as well as the in vivo application of small interfering RNA (siRNA) as a novel approach to the inhibition of ALI and its therapeutic implications.
Divergent Effects of Neutrophils on Fas-Induced Pulmonary Inflammation, Apoptosis, and Lung Damage
TLDR
Neutrophils are a necessary component of Fas-induced lung damage, while not affecting lung apoptosis directly per se, and display higher resistance to Fas-triggered inflammation and apoptosis than AM.
Role of chemokines in the pathogenesis of acute lung injury.
TLDR
Excessive recruitment of leukocytes is critical to the pathogenesis of ALI, and the magnitude and duration of the inflammatory process may ultimately determine the outcome in patients with ALI.
Divergent Effects of Activated Neutrophils on Inflammation, Kupffer Cell/Splenocyte Activation, and Lung Injury Following Blunt Chest Trauma
TLDR
In response to lung trauma, activated neutrophils control inflammation including mediator release from distant immune cells but simultaneously mediate pulmonary tissue damage, which might be a reasonable therapeutic approach in chest trauma–induced lung injury.
The mercurial nature of neutrophils: still an enigma in ARDS?
  • A. WilliamsR. Chambers
  • Medicine, Biology
    American journal of physiology. Lung cellular and molecular physiology
  • 2014
TLDR
Experimental and clinical evidence supporting neutrophils as key players in ARDS and the chemokine network in the inflamed lung is complex and may involve several other chemokines, including CXCL10, CCL2, and CCL7.
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury.
TLDR
It is proposed that lung injury in response to immune complex deposition is dependent on Rac2 in alveolar macrophages and neutrophils, and that Rac2 is important in mediating lung injury.
Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.
RATIONALE The involvement of neutrophil activation in the sentinel, potentially reversible, events in the pathogenesis of acute lung injury (ALI) is only partially understood. alpha-Defensins are the
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