Neutrophils aid in protection of the vaginal mucosae of immune mice against challenge with herpes simplex virus type 2.

@article{Milligan1999NeutrophilsAI,
  title={Neutrophils aid in protection of the vaginal mucosae of immune mice against challenge with herpes simplex virus type 2.},
  author={Gregg N. Milligan},
  journal={Journal of virology},
  year={1999},
  volume={73 8},
  pages={6380-6}
}
Large numbers of polymorphonuclear leukocytes (PMNs) infiltrated the murine vaginal mucosa within 24 h after intravaginal inoculation with an attenuated strain of herpes simplex virus type 2 (HSV-2). The role of these cells in resolution of a primary genital infection and in protection of HSV-immune animals against challenge with a fully virulent HSV-2 strain was investigated. Depletion of greater than 95% of the PMNs at the vaginal mucosal surface prior to intravaginal inoculation with an… CONTINUE READING