Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.

@article{Gujral2003NeutrophilsAA,
  title={Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.},
  author={Jaspreet S Gujral and Anwar Farhood and Mary Lynn Bajt and Hartmut Jaeschke},
  journal={Hepatology},
  year={2003},
  volume={38 2},
  pages={355-63}
}
Obstruction of the common bile duct in a variety of clinical settings leads to cholestatic liver injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the prominent cell type involved. However, the pathophysiologic role of the infiltrating neutrophils during cholestatic liver injury remains unclear. Therefore, we tested the… CONTINUE READING