Neutrophils Exert a Suppressive Effect on Th1 Responses to Intracellular Pathogen Brucella abortus

@inproceedings{BarqueroCalvo2013NeutrophilsEA,
  title={Neutrophils Exert a Suppressive Effect on Th1 Responses to Intracellular Pathogen Brucella abortus},
  author={El{\'i}as Barquero-Calvo and Anna S. Martirosyan and Diana Ordo{\~n}ez-Rueda and Vilma Arce-Gorvel and Alejandro Alfaro-Alarc{\'o}n and Hubert L{\'e}pidi and Bernard Malissen and Marie Malissen and Jean-Pierre E. Gorvel and Edgardo Moreno},
  booktitle={PLoS pathogens},
  year={2013}
}
Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the influence of PMNs in the immune response during chronic bacterial infections, we explored the course of brucellosis in antibody PMN-depleted C57BL/6 mice and in neutropenic mutant Genista mouse model. We demonstrate that at later times of infection, Brucella abortus is killed… CONTINUE READING
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