Neutrophils Are Resistant to Yersinia YopJ/P-Induced Apoptosis and Are Protected from ROS-Mediated Cell Death by the Type III Secretion System

@inproceedings{Spinner2010NeutrophilsAR,
  title={Neutrophils Are Resistant to Yersinia YopJ/P-Induced Apoptosis and Are Protected from ROS-Mediated Cell Death by the Type III Secretion System},
  author={Justin L. Spinner and Keun Seok Seo and Jason L. O'Loughlin and Jennifer A. Cundiff and Scott A. Minnich and Gregory A. Bohach and Scott D. Kobayashi},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The human innate immune system relies on the coordinated activity of macrophages and polymorphonuclear leukocytes (neutrophils or PMNs) for defense against bacterial pathogens. Yersinia spp. subvert the innate immune response to cause disease in humans. In particular, the Yersinia outer protein YopJ (Y. pestis and Y. pseudotuberculosis) and YopP (Y. enterocolitica) rapidly induce apoptosis in murine macrophages and dendritic cells. However, the effects of Yersinia Yop J/P on… CONTINUE READING
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