Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17.

@article{Miyamoto2003NeutrophiliaIL,
  title={Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17.},
  author={Mamiko Miyamoto and Masashi Emoto and Yoshiko Emoto and V Brinkmann and Izumi Yoshizawa and Peter Seiler and Peter Aichele and Eiji Kita and Stefan H. E. Kaufmann},
  journal={Journal of immunology},
  year={2003},
  volume={170 10},
  pages={5228-34}
}
LFA-1 (CD11a/CD18) plays a crucial role in various inflammatory responses. In this study, we show that LFA-1(-/-) mice are far more resistant to Listeria monocytogenes infection than LFA-1(+/-) mice. Consistent with this, we found the following: 1) the numbers of granulocytes infiltrating the liver were markedly higher in LFA-1(-/-) mice than in LFA-1(+/-) mice, 2) increased antilisterial resistance in LFA-1(-/-) mice was abrogated by depletion of granulocytes, and 3) the numbers of… CONTINUE READING