Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway.

@article{Simon2000NeutrophilTO,
  title={Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway.},
  author={Scott I Simon and Yu Cheng Hu and Dietmar Vestweber and Clifton Smith},
  journal={Journal of immunology},
  year={2000},
  volume={164 8},
  pages={4348-58}
}
On inflamed endothelium selectins support neutrophil capture and rolling that leads to firm adhesion through the activation and binding of beta 2 integrin. The primary mechanism of cell activation involves ligation of chemotactic agonists presented on the endothelium. We have pursued a second mechanism involving signal transduction through binding of selectins while neutrophils tether in shear flow. We assessed whether neutrophil rolling on E-selectin led to cell activation and arrest via beta… CONTINUE READING
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