Neutrophil short-lived oxidant production: enhancement following onset of sepsis-induced lung injury.

@article{Carey1992NeutrophilSO,
  title={Neutrophil short-lived oxidant production: enhancement following onset of sepsis-induced lung injury.},
  author={P. Declan Carey and J K Jenkins and K. E. Byrne and Andreas M Schneider and Ch. Walsh and Alpha A Berry Fowler and Harvey J. Sugerman},
  journal={Circulatory shock},
  year={1992},
  volume={36 4},
  pages={256-64}
}
Generation of superoxide anion (O2-) by activated neutrophils (PMN) is implicated in the pathogenesis of endothelial cell injury in sepsis. To quantitate this phenomenon we studied the kinetics of O2- production by PMN following in vivo and in vitro exposure to Pseudomonas aeruginosa. PMN were isolated from young swine before and after a 1-hr infusion with 5 x 10(8) organisms/ml at 0.3 ml/20 kg/min. Baseline PMN were studied in an in vitro system where 1 x 10(6) porcine PMN were incubated with… CONTINUE READING