Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis.

@article{Don2003NeutrophilRB,
  title={Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis.},
  author={Massimo Don{\`a} and Isabella Dell'Aica and Fiorella Calabrese and Roberto Benelli and Monica Morini and Adriana Albini and Spiridione Garbisa},
  journal={Journal of immunology},
  year={2003},
  volume={170 8},
  pages={4335-41}
}
Neutrophils play an essential role in host defense and inflammation, but the latter may trigger and sustain the pathogenesis of a range of acute and chronic diseases. Green tea has been claimed to exert anti-inflammatory properties through unknown molecular mechanisms. We have previously shown that the most abundant catechin of green tea, (-)epigallocatechin-3-gallate (EGCG), strongly inhibits neutrophil elastase. Here we show that 1) micromolar EGCG represses reactive oxygen species activity… CONTINUE READING