Neutrophil recruitment as a factor limiting injury or promoting recovery from acute lung injury.

@article{Carey1997NeutrophilRA,
  title={Neutrophil recruitment as a factor limiting injury or promoting recovery from acute lung injury.},
  author={Lisa A. Carey and Sandra Z Perkowski and Caren Lipsky and Raymond A. Cirelli and J A Spath and M H Gee},
  journal={The American journal of physiology},
  year={1997},
  volume={272 1 Pt 2},
  pages={H279-89}
}
We studied 1) neutrophil mobilization in sheep given endotoxin (10 ng.kg-1.min-1, n = 5) for 4 h, 2) surviving (n = 17) and nonsurviving sheep (n = 8) during a 12-h infusion of endotoxin, and 3) adult sheep (n = 8) or lambs (n = 8) infused with endotoxin for 12 h. Bone marrow cells of sheep declined from a baseline value of 10,533 +/- 1,784 to 5,966 +/- 1,980 cells/microliter (P < 0.05) 4 h after endotoxin. After 12 h of endotoxin infusion, circulating neutrophils remained reduced from baseline… CONTINUE READING