Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.

@article{Saadoun2012NeutrophilPI,
  title={Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.},
  author={Samira Saadoun and Patrick H. Waters and Claire Macdonald and B. Anthony Bell and A Onodugo Vincent and Alan S Verkman and Marios C Papadopoulos},
  journal={Annals of neurology},
  year={2012},
  volume={71 3},
  pages={
          323-33
        }
}
OBJECTIVE Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4). The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neutrophils are not generally found in multiple sclerosis lesions. We evaluated the role of neutrophils in a mouse NMO model. METHODS NMO lesions were produced in mice by intracerebral injection of… CONTINUE READING
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