Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease

@inproceedings{Margaroli2016NeutrophilPE,
  title={Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease},
  author={Camilla Margaroli and Rabindra Tirouvanziam},
  booktitle={Molecular and cellular pediatrics},
  year={2016}
}
INTRODUCTION The pathological course of several chronic inflammatory diseases, including cystic fibrosis, chronic obstructive pulmonary disease, and rheumatoid arthritis, features an aberrant innate immune response dominated by neutrophils. In cystic fibrosis, neutrophil burden and activity of neutrophil elastase in the extracellular fluid have been identified as strong predictors of lung disease severity. REVIEW Although neutrophils are generally considered to be rigid, pre-programmed… CONTINUE READING
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