Neutrophil-oxidized low density lipoprotein: generation in and clearance from the plasma.

@article{Grg1992NeutrophiloxidizedLD,
  title={Neutrophil-oxidized low density lipoprotein: generation in and clearance from the plasma.},
  author={P{\'e}ter G{\"o}r{\"o}g},
  journal={International journal of experimental pathology},
  year={1992},
  volume={73 4},
  pages={
          485-90
        }
}
The prevailing concept of an extremely rapid disappearance of 'modified' low density lipoprotein (LDL) from the circulation was reinvestigated. Rabbit LDL was 'modified' by homologous activated (phagocytosing) polymorphonuclear leucocytes (PMLN), radiolabelled with a non-degradable ligand (125I-TC-LDL) and injected into rabbits. The plasma half-lives of 'modified' and native LDL were T1/2 = 2.5 and 5.75 h, respectively. Furthermore, the possibility of LDL oxidation in plasma by stimulated PMNL… CONTINUE READING

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