Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms.

@article{Rutgers2003NeutrophilMA,
  title={Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms.},
  author={Abraham Rutgers and Peter Heeringa and Joyce E H M Giesen and Ruud T Theunissen and Heinz Jacobs and Jan Willem Cohen Tervaert},
  journal={British journal of haematology},
  year={2003},
  volume={123 3},
  pages={536-8}
}
Myeloperoxidase (MPO) catalyses the formation of hypochlorous acid and is involved in many (patho)physiological processes. The present study was designed to determine the effect of two MPO promoter polymorphisms (463G/A and 129G/A) on enzyme activity. In 243 healthy controls, genotypes were determined and MPO activity was measured on a single-cell level using a haematological analyser. The 129G/A polymorphism reduces MPO activity in neutrophils, whereas for the 463G/A polymorphism, only gender… CONTINUE READING

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