Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea.

@article{Tumpey1996NeutrophilmediatedSO,
  title={Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea.},
  author={Terrence M. Tumpey and San - Hwan Chen and John E. Oakes and Robert N. Lausch},
  journal={Journal of virology},
  year={1996},
  volume={70 2},
  pages={898-904}
}
Herpes simplex virus type 1 (HSV-1) infection of the murine cornea induces the rapid infiltration of neutrophils. We investigated whether these cells could influence virus replication. BALB/c mice treated with monoclonal antibody (MAb) RB6-8C5 experienced a profound depletion of neutrophils in the bloodstream, spleen, and cornea. In these animals, virus titers in the eye were significantly higher than those in the immunoglobulin G-treated controls at 3 days postinfection. By day 9, virus was no… CONTINUE READING

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