Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

  title={Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.},
  author={John Harlan and Paul D. Killen and Laurence A. Harker and Gary E. Striker and Daniel G. Wright},
  journal={The Journal of clinical investigation},
  volume={68 6},
Neutrophil-mediated endothelial injury was assessed in vitro using assays of cell lysis and cell detachment. Activation of human peripheral blood neutrophils adherent to human umbilical vein endothelial cell monolayers by serum-treated zymosan produced dose-dependent endothelial cell detachment without concomitant cell lysis. This injury was inhibited by neutral protease inhibitors, but not by catalase or superoxide dismutase. Neutrophils from a patient with chronic granulomatous disease also… CONTINUE READING


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